Abstract: Mixture design was employed to determine optimal proportions of the three diet ingredients, sugar, yeast and wheat bran, for the oriental fruit fly, Bactrocera dorsalis. Pupation rate, larval duration, pupal weight, sex ratio, oviposition, hatchability were correlated to diet ingredients to optimize the ingredient composition and the interaction among diet ingredients. We obtained the most predictable highest pupation rate of 100%, the shortest larval duration of 7.73 d, the biggest pupal weight of 17.76 mg, the most ideal sex ratio of 1.00, the highest fecundity of 381.22, the highest egghatching rate of 78.25%. With the exception of fecundity, there were interactive effects among the ingredients on the other parameters. Two optimal formulations of the ingredients, 11.04% sugar, 3.27% yeast and 25.69% wheat bran, and 12.11% sugar, 3.00% yeast and 24.89% wheat bran, were identified. The two formulations produced desired results. The mixture design method can be applied to develop or improve artificial diets of insects.