Abstract: Corn is a major food crop in the world. Corn borers are the most destructive insect pests, which can substantially reduce the yield and quality of corn. Chemical control and genetically modified insect resistant corn could effectively control corn borer damage to certain degree. However, as the environmental and food safety concerns caused by insecticide application and increasing public concern of genetically modified insect resistant corn in food and ecological safety, the research of corn resistance mechanisms to corn borers is of more important significance in reducing corn borer damage. Mechanisms of resistance to stem borers, including physiological and biochemical factors, such as secondary metabolites, cell wall structure component and physical structure, were summarized in this paper. Also, suggestions and prospects of further research were put forward on base of the summary.