Base Editing Technology and Its Application and Prospect in Insects

doi:10.16409/j.cnki.2095-039x.2021.03.003

Abstract

Abstract: Gene editing is a kind of genetic engineering technology that can modify specific target genes in the genome of an organism. In recent years, gene editing technology constantly breakthroughs and develop. Based CRISPR system, researchers have focused on the single-base editor and prime editor techniques. With the development of gene editing technology, it has been successfully applied to various kinds of animals and plants and other organisms, and provides important technical support for gene therapy and gene function researches. This paper mainly reviews the development and application of the three technologies, including CRISPR/Cas technology, single-base editing technology and the newly developed prime editing technology, and the future development and application are also prospected.

Key words: CRISPR/Cas, base editing technique, prime editing

CLC Number:

Q963

WANG Xiaodi, JI Shunxia, SHEN Xiaona, LIU Wanxue, WAN Fanghao, ZHANG Guifen, Lü Zhichuang. Base Editing Technology and Its Application and Prospect in Insects[J]. Chinese Journal of Biological Control, 2021, 37(3): 609-619.

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