非核糖体肽-聚酮-多胺类天然产物福莱菌肽和玉米胺研究进展

doi:10.16409/j.cnki.2095-039x.2026.02.029

摘要/Abstract

摘要： 非核糖体肽-聚酮-多胺类天然产物是一类结构新颖的天然产物，其对植物病原细菌、真菌和线虫具有良好的防治效果，在植物病害防治方面具有广阔的应用前景，有望被开发为一类新型生物农药。本文就非核糖体肽-聚酮-多胺类天然产物福莱菌肽和玉米胺的生物合成和调控机制、结构多样性和生物活性以及高产工程菌株构建等方面研究进展做详细介绍，并展望其未来的研究重点。

关键词: 非核糖体肽-聚酮-多胺类天然产物, 福莱菌肽, 玉米胺

Abstract: Non-ribosomal peptide-polyketide-polyamine (NRPs-PKs-PAs) natural products are a class of structurally distinctive compounds that demonstrate potent inhibitory effects against plant pathogenic bacteria, fungi, and nematodes. Due to their broad-spectrum biological activity, these compounds show great promise for the control of plant diseases, making them promising candidates for the development of new biopesticides. This article provides a comprehensive overview of the research advancements in the biosynthetic and regulatory mechanisms, structural diversity and biological activities, as well as the development of high-yield engineered strains of non-ribosomal peptide-polyketide-polyamine natural products, specifically Fabclavine and Zeamine, while also offering perspectives on future research directions.

Key words: NRPs-PKs-PAs, fabclavine, zeamine

中图分类号:

S476

尹长琰, 李广悦. 非核糖体肽-聚酮-多胺类天然产物福莱菌肽和玉米胺研究进展[J]. 中国生物防治学报, 2026, 42(2): 480-488.

YIN Changyan, LI Guangyue. Research Advances in Fabclavine and Zeamine, Non-Ribosomal Peptide-Polyketide-Polyamine Natural Products[J]. Chinese Journal of Biological Control, 2026, 42(2): 480-488.

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