Research Advances in Fabclavine and Zeamine, Non-Ribosomal Peptide-Polyketide-Polyamine Natural Products

doi:10.16409/j.cnki.2095-039x.2026.02.029

Abstract

Abstract: Non-ribosomal peptide-polyketide-polyamine (NRPs-PKs-PAs) natural products are a class of structurally distinctive compounds that demonstrate potent inhibitory effects against plant pathogenic bacteria, fungi, and nematodes. Due to their broad-spectrum biological activity, these compounds show great promise for the control of plant diseases, making them promising candidates for the development of new biopesticides. This article provides a comprehensive overview of the research advancements in the biosynthetic and regulatory mechanisms, structural diversity and biological activities, as well as the development of high-yield engineered strains of non-ribosomal peptide-polyketide-polyamine natural products, specifically Fabclavine and Zeamine, while also offering perspectives on future research directions.

Key words: NRPs-PKs-PAs, fabclavine, zeamine

CLC Number:

S476

YIN Changyan, LI Guangyue. Research Advances in Fabclavine and Zeamine, Non-Ribosomal Peptide-Polyketide-Polyamine Natural Products[J]. Chinese Journal of Biological Control, 2026, 42(2): 480-488.

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