Microbial pesticide, are the bio-control agents that utilize microbes or their metabolites to control disease, insect, grass, rats and other harmful organisms, and to protect or promote plant growth. In recent years, because of the abuse of chemical pesticides, the problem of pest resistance, pesticide residues and environmental pollution is getting worse, while the microbial pesticide, as the substitute to chemical pesticides, are playing an increasingly important role. In this paper, we reviewed the development course of microbial pesticide registration and management globally, summarizes the material requirements for microbial pesticide registration and management. And then, we analyze the present status of microbial pesticide registration and management based on the present situation of agricultural in China, and make recommendations for further improve the microbial pesticide registration and management in China.