Abstract: Cydia pomonella (L.) is an important quarantine pest in China, which has so far invaded in Xinjiang, Gansu, Ningxia, Inner Mongolia, Heilongjiang and Jilin provinces, and poses a serious threat to China apple industry. Now, traditional control methods have been based predominantly on broad spectrum insecticides in China. Considering food safety, environmental impact, and sustainability of synthetic pesticides, people have started to pay attention to IPM, in which biological control plays a key role. A variety of biocontrol agents of C. pomonella have been reviewed in this paper, including Bacillus thuringiensis, Beauveria bassiana, granulovirus, entomopathogenic nematodes (EPNs) and parasitic wasp. The role of biological control in IPM in the orchard agroecosystem was discussed, including the problems and the application prospect of biological control, in order to provide a reference for IPM strategy and its application in C. pomonella management.