Review on Secondary Antibiotic Metabolites of Bacillus velezensis

doi:10.16409/j.cnki.2095-039x.2022.02.007

Abstract

Abstract: Bacillus velezensis is widely distributed in nature. Its antibiotic metabolites are very abundant and have the potential to be developed as new biological control agents. Its genome contains a lot of biosynthetic gene clusters of antibiotic metabolites, such as surfactin, fengycin, bacillomycin-D and other lipopeptide compounds, bacillaene, macrolactin, difficidin and other polyketides, as well as bacillibactin and bacilysin, etc. The synthesis of majority of secondary antibiotic substances by Bacillus velezensis rely on the 4'-phosphopanonyl transferase (Sfp) pathway for synthesis, except bacilysin. This article summarizes and generalizes the chemical structure of secondary antibiotic substances, biosynthetic gene clusters and their regulatory mechanisms of B. velezensis, and their application in the controlling of plant, animal and human diseases, so as to provide scientific basis for developing Bacillus velezensis and the metabolites as biocontrol preparations or clinical drugs in the future.

Key words: Bacillus velezensis, antibiotic metabolites, lipopeptides, polyketides

CLC Number:

S476

YANG Bing, DU Chunmei. Review on Secondary Antibiotic Metabolites of Bacillus velezensis[J]. Chinese Journal of Biological Control, 2022, 38(2): 502-512.

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